Exclude both the global.asa directory as well as the actual file itself from your virus scans on any server where an APE is running. If you do not, you will see a very frequent "HTTP 1.1 Application Restarting" Errors.

Once dissabled the errors stop immediately. Here is a link to a Q article at msdn that explains a little about the error: http://support.microsoft.com/support/kb/articles/q248/0/13.asp

The actual Vignette KB article that talks about it is entitled "Disable Virus Scan When Running Windows 2000 and IIS 5.0" and its number is 2753.